- Automated cell population identification
- Result visualization in 2D and 3D
- Statistical analysis of population characteristics
- Automated mapping of populations across multiple samples
|Resources||News & Events|
ImmPort is a long-term, sustainable data warehouse for the purpose of promoting re-use of immunological data generated by NIAID DAIT and DMID funded investigators.
ImmPort supports analysis of flow cytometry results and HLA genetic associations.
Variation in influenza vaccine response is the result of both patient-specific expression changes and shared changes that vary in their timing. To understand these overlapping events, vaccine response was monitored using RNA seq, flow cytometry, and ELISPOT with improved temporal resolution. By using functional principal component analysis to analyze B cell response daily, correlations between vaccine history, cellular response, and gene expression were investigated. Using this approach, a common gene expression pattern correlated with migrating plasma cells was found in previously vaccinated subjects.
The emergence of drug-resistant influenza strains over time can make drug discovery of effective anti-viral treatments a moving target. To identify host genes required for influenza replication, an siRNA screen of proteases was conducted in epithelial cells. Five potential targets were found to be required for virus replication. Pathway analysis found these five proteases to be components of inflammation, cAMP/calcium signaling, and apoptosis pathways and to be potentially regulated by endogenous miRNAs. Further assays confirmed several of these miRNAs as regulators of protease expression and additional potential targets for anti-viral drugs.
The immune system generates antibodies less effectively against the second of two closely related viruses when sequentially challenged, a phenomenon known as original antigenic sin. Mice were sequentially challenged with two related H1N1 influenza strains using pertussis toxin, CpG oligonucleotides, and nanoemulsion as adjuvant. Use of adjuvant with the second challenge was found to improve immune response. Additionally, use of pertussis toxin or nanoemulsion as adjuvant with the first challenge was also found to improve response to a subsequent challenge without adjuvant.
immuneXpresso is now in ImmPort-Labs!
iX is an information extraction system using Natural Language Processing to create a global network of cell-cytokine interactions.
Inclusion of relevant disease, tissue and drug information enhances the semantically derived network.
|Flow Cytometry Results||68942|
|Gene Expression Results||28086|
|HLA Typing Results||2497|
| Neutralizing Antibody |